Test Results For:
Cyclosporine
Test Overview
- Test Name
-
Cyclosporine
- Test Code
- CYCLO
Short Description
Cyclosporine
Test Name
Cyclosporine
Test Code
CYCLO
Category
Biochemistry
TAT
Main Lab:
6
Hour(s)
Family Site:
<6hrs
Specimen(s)
1 x Venous blood - 5 mL Tube - Lavender - EDTA Whole Blood
Specimen Type
EDTA Whole Blood
Specimen Format
Tube
Specimen Colour
Lavender
Specimen Volume
5 mL
Sampling Order
4
Origin
Venous blood
Collection Time after baseline
-
Transport Temperature
-20°C
Accepted Other Specimens
-
TAT
Main Lab:
6
Hour(s)
Family Site:
<6hrs
Test Stability
Room Temp:
-
2–8°C:
7 Day(s)
Methodology
-
Specimen Type
EDTA Whole Blood
Delay before pre-treatment
7
Transport temperature
-20°C
Test stability at room temperature
-
Test stability at 2–8°C
7 Day(s)
Haemolysis interference
No
Clinical Interest
Cyclosporin is widely used to prevent rejection in patients who have undergone organ transplants, particularly kidney, liver, heart or lung transplants. The drug works by suppressing the immune system, thereby reducing the risk of rejection. Cyclosporine has a narrow therapeutic window, meaning that the difference between effective and toxic doses is small.
Cyclosporine can cause significant side effects, particularly when blood levels are high. Nephrotoxicity (kidney damage) is one of the most common and serious side effects, as cyclosporine can reduce renal blood flow and glomerular filtration rate. Neurotoxicity, including tremors, convulsions and headaches, is another undesirable effect.
Regular monitoring of ciclosporin blood levels ensures that the concentration of the drug is sufficient to prevent rejection but not so high as to cause toxicity.
Immediately after transplantation, patients have the highest risk of organ rejection, requiring higher doses of cyclosporine. Over time, the dose can be reduced, but careful monitoring with analyses is necessary to determine the appropriate reduction schedule while ensuring continued protection against rejection.
Clinical Information Required
Date of last medication taken
Patient Collection Note
-
LOINC Code
20-4, 3520-4
Outwork
No